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KMID : 0384620070180010042
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Korean Journal of Medical Physics
2007 Volume.18 No. 1 p.42 ~ p.47
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The Study of in Vivo Visual Pathway Tracing using Magnetic Magnanese Tracer
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Bae Sung-Jin
Chang Yong-Min
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Abstract
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Purpose:To evaluate the tracing of optic nerve tract using manganese enhanced magnetic resonance Imaging.
Materials and Methods:After injecting 30{mu} of MnCl_2(1mol) (1 mol) Into the retina of female New Zealand white rabbit, the contrast enhancements at major anatomical structures of optic nerve tract were evaluated by high resolution T1-weighted Images 12 hours, 24 hours, and 48 hours after MnCl_2(1mol) Injection using 3D FSPGR (Fast Speiled Gradient Recalled echo) pulse sequence at 1.5T clinical MR scanner with high performance gradient system. Also, for quantitative evaluation, the signal-to-noise ratios of circular ROI on anatomical locations were measured.
Results:The major structures on the optic nerve tract were enhanced after injecting MnCl_2(1mol). The structures, which showed enhancement, were right optic nerve, optic chiasm, left optic tract, left lateral geniculate nucleus, left superior colliculus. The structures on the contralateral optic pathway to the right retina were enhanced whereas the structures on the ipsilateral pathway did not show enhancement.
Conclusion: The Mn transport through axonal pathway of optic nerve sys)em was non- invasively observed after injecting injecting MnCl_2 at the retina, which is the end terminal of optic nerve system. This Mn transport seems to occur by voltage gated calcium (Ca^{2+}) channel and In case of direct Injection Into the retina, the fast transpori pathway of voltage gated calcium channel seems to be responsible for Mn transport.
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KEYWORD
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Manganese, Magnetic resonance Imaging, Optic nervous system
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